| Adorf, Mario | born 1930 | Actor |
| Ahnen, Doris | born 1964 | Politician (SPD), Minister of Finance for Rhineland-Palatinate |
| Ahrens, Arne | born 1975 | Director, screenwriter and film producer |
| Allen, John | born 1984 | Musician |
| Anders, Thomas | born 1963 | Pop singer, producer |
| Bastian, Till | born 1949 | Physician, publicist and author |
| Bilke, Jörg Bernhard | born 1932 | Journalist, arrested and imprisoned by the Stasi for critical articles about the GDR |
| Binz, Katharina | born 1982 | Politician (Greens), Minister for Family, Women, Culture and Integration in Rhineland-Palatinate since 2021 |
| Blume, Felix | born 1984 | Rapper |
| Böhmer, Maria | born 1950 | Politician (CDU), Federal Commissioner for Migration, Refugees and Integration |
| Bratzler, Clemens | born 1972 | TV presenter |
| Brauchitsch, Eberhard von | 1926-2010 | Manager, director of the Flick Group |
| Braunmühl, Gerold von | 1935-1986 | Diplomat, RAF victim |
| Brüderle, Rainer | born 1945 | Politician (FDP), former Minister of Economics |
| Caspary, Roland A. | 1931-2013 | Film policy officer, head of the Federal Film Board |
| Chantraine, Heinrich | 1929-2002 | Ancient historian, former Dean of the University of Mannheim |
| Charm, Lee | born 1954 | South Korean TV presenter, actor and politician |
| Cordes, Paul Josef | born 1934 | Cardinal, former Auxiliary Bishop of Paderborn |
| de la Motte-Haber, Helga | born 1938 | Musicologist |
| Dietze, Roderich | 1909-1960 | Sports reporter, international table tennis player |
| Drees, Jochen | born 1970 | Doctor, Bundesliga referee |
| Dreyer, Malu | born 1961 | Politician (SPD), Prime Minister of Rhineland-Palatinate |
| Duppré, Hans Jörg | born 1945 | Politician (CDU), President of the German District Council |
| Ebling, Michael | born 1967 | Politician (SPD), Interior Minister of Rhineland-Palatinate |
| Falkenberg, Karl Friedrich | born 1952 | Director General for the Environment of the EU Commission |
| Fischer-Münster, Gerhard | born 1952 | Composer, conductor, pianist |
| Fleckenstein, Josef | 1919-2004 | Historian |
| Forster, Mark | born 1983 | Singer and songwriter |
| Frey, Peter | born 1957 | Editor-in-chief of the ZDF |
| Friderichs, Hans | born 1931 | Politician (FDP), former Minister of Economics |
| Friedman, Michel | born 1956 | Politician (CDU), TV presenter, former chairman of the Central Council of Jews |
| Gause, Gundula | born 1965 | News anchor |
| Gerster, Johannes | 1941-2021 | Politician (CDU), former state chairman of the CDU in Rhineland-Palatinate |
| Giebelmann, Dietmar | born 1946 | Vicar General of the Diocese of Mainz |
| Gienger, Eberhard | born 1951 | Gymnast, Olympic bronze medalist 1976 |
| Glotzbach, Michael | born 1947 | Diplomat, German Ambassador to Chile |
| Guballa, Werner | 1944-2012 | Auxiliary Bishop of Mainz |
| Haase, Nino | born 1983 | Politician (independent), Lord Mayor of Mainz |
| Hahner, Anna | born 1989 | Track and field athlete and long-distance runner |
| Hahner, Lisa | born 1989 | Track and field athlete and long-distance runner |
| Hartmann, Michael | born 1963 | Politician (SPD), domestic policy spokesperson for the SPD parliamentary group |
| Heimbach, Jürgen | born 1961 | Writer |
| Helmes, Werner | 1925-2008 | Writer |
| Hempelmann, Heinzpeter | born 1952 | Protestant theologian and philosopher |
| Hess, Reimund | born 1935 | Journalist and composer |
| Hesse, Konrad | 1919-2005 | Constitutional judge |
| Heyen, Franz Josef | 1928-2012 | Director of the Koblenz State Archives |
| Hollmann, Michael | born 1961 | President of the Federal Archives |
| Huberty, Ernest | 1927-2023 | Sports journalist, moderator of "Sportschau" |
| Humberg, Christian | born 1976 | Author, translator, journalist |
| Hüsch, Hanns Dieter | 1925-2005 | Cabaret artist |
| Jakobs, Hans-Jürgen | born 1956 | Economist and journalist, editor-in-chief of “Handelsblatt” |
| Jung, Franz Josef | born 1949 | Politician (CDU), 2005-2009 Federal Minister of Defense |
| Kahlenberg, Friedrich P. | 1935-2014 | 1989-1999 President of the Federal Archives |
| Kaldemorgen, Klaus | born 1953 | Economist and fund manager |
| Kaul, Niklas | born 1998 | World decathlon champion |
| Klöckner, Julia | born 1972 | Politician (CDU), Federal Minister of Agriculture, State Chair of the Rhineland-Palatinate CDU |
| Klosterkamp, Thomas | born 1965 | Theologian, General Postulator for Beatifications and Canonizations, 2007-2013 Provincial of the Central European Province of the Oblates |
| Kratschmer, Guido | born 1953 | Decathlete, Olympic silver medalist 1976 |
| Kühl, Carsten | born 1962 | Politician (SPD), 2009-2014 Finance Minister of Rhineland-Palatinate |
| Lambrecht, Christine | born 1965 | Politician (SPD), 2019-2021 Federal Minister of Justice, since 2021 Federal Minister of Defense |
| Lautenschläger, Silke | born 1968 | Politician (CDU), 2009-2010 Minister for Social Affairs and Minister for the Environment in Hesse |
| Linden, Michael | born 1948 | Neurologist and psychiatrist |
| Liz, Sheila de | born 1969 | Gynaecologist and author |
| Ludwig, Irene | 1927-2010 | Art historian and patron |
| Ludwig, Peter | 1925-1996 | Industrialist and art patron |
| Mann, Tobias | born 1976 | Cabaret artist and entertainer |
| Massenkeil, Günther | 1926-2014 | Musicologist and concert singer |
| Mertin, Herbert | born 1958 | Politician (FDP), Attorney General in Rhineland-Palatinate 1999-2006 and since 2016 |
| Meschenmoser, Sebastian | born 1980 | Artist and children's book author |
| Meyer-Grönhoff, Gernot | born 1951 | Painter and sculptor |
| Mickler-Becker, Ingrid | born 1942 | Track and field athlete, Olympic gold medalist 1968 |
| Müller, Gerhard Ludwig | born 1947 | Theologian, 2002-2012 Bishop of Regensburg, 2012-2017 Prefect of the Vatican Congregation for Faith |
| Müller, Rolf Dieter | born 1948 | Military historian, Department Head at the Military History Research Office |
| Muth, Jakob | 1927-1993 | Educator, pioneer of inclusive schools |
| Mützelburg, Bernd | born 1944 | Diplomat, 2006-2009 German Ambassador to India |
| Neymeyr, Ulrich | born 1957 | Theologian, Bishop of Erfurt |
| Nguyen-Kim, Mai Thi | born 1987 | Chemist, presenter, author, YouTuber |
| Ortheil, Hanns-Josef | born 1951 | Writer |
| Parvis, Yasmin | born 1977 | TV presenter (heute plus) |
| Pfeiffer, Alexander | born 1971 | Writer |
| Pharo, Miriam | born 1966 | Writer |
| Pick, Eckhart | born 1941 | Lawyer, politician (SPD) |
| Pohlmann, Dirk | born 1959 | Screenwriter and film director |
| Quandt, Bernhard | born 1954 | see Charm, Lee |
| Reda, Felix (formerly: Julia Reda) |
born 1986 | Politician, 2014-2019 member of the European Parliament |
| Reichow, Lars | born 1964 | Music cabaret artist |
| Reif, Marcel | born 1949 | TV journalist and sports commentator |
| Réthy, Béla | born 1956 | Sports reporter |
| Rohwedder, Detlev Karsten | 1932-1991 | Manager, chairman of the Trust Agency, RAF victim |
| Rupp, Rainer | born 1945 | Journalist, East German foreign espionage agent (code name “Topas”) |
| Rutzen, Franz | born 1933 | Publisher |
| Saalfrank, Katharina | born 1971 | Educator, columnist, author (Super-Nanny) |
| Schächter, Markus | born 1949 | Journalist, 2002-2012 Director of ZDF |
| Schenk, Franziska | born 1974 | Speed skater, TV presenter |
| Schmid, Harald | born 1957 | Track and field athlete and Olympic medalist |
| Schmitz, Georg | born 1958 | Composer and music teacher |
| Schoen, Hartmut | born 1951 | Screenwriter, film director and producer |
| Scholl-Latour, Peter | 1924-2014 | Journalist and publicist |
| Schönbach, Klaus | born 1949 | Media scholar |
| Schöne, Lothar | born 1949 | Journalist and writer |
| Schreiter, Johannes | born 1930 | Painter, graphic designer, glass artist |
| Schröder, Kristina | born 1977 | Politician (CDU), 2009-2013 Federal Minister for Family Affairs |
| Schröder, Tom | born 1938 | Music journalist and presenter |
| Schweitzer, Alexander | born 1973 | Politician (SPD), 2013-2014 Minister of Social Affairs of Rhineland-Palatinate, since 2021 Minister of Labor and Social Affairs of Rhineland-Palatinate |
| Sorg-Rose, Margarete | born 1960 | Composer and conductor |
| Spiegel, Anne | born 1980 | Politician (Greens), 2016-2021 Minister in Rhineland-Palatinate, 2021 Federal Minister for Family Affairs |
| Stark-Watzinger, Bettina | born 1968 | Politician (FDP), since 2021 Federal Minister of Education and Research |
| Stipp, Christa | born 1990 | Meteorologist, TV presenter |
| Stolte, Dieter | born 1934 | Journalist, 1982-2002 Director of ZDF |
| Strasser, Johano | born 1939 | Political Scientist, Writer, President of the PEN Club |
| Strutz, Harald | born 1950 | Track and field athlete, 1988-2017 president of FSV Mainz 05 |
| Töpfer, Klaus | born 1938 | Politician (CDU), 1987-1994 Federal Minister for the Environment |
| Trabant-Haarbach, Anne | born 1949 | Soccer player, assistant coach of the German women's national soccer team |
| Trabert, Gerhard | born 1956 | Social medicine practitioner |
| Türck, Andreas | born 1968 | Radio and television presenter |
| Wagner, Carl-Ludwig | 1930-2012 | Politician (CDU), 1988-1991 Minister President of Rhineland-Palatinate |
| Wintermantel, Margret | born 1947 | President of the DAAD, 2000-2006 Rector of Saarland University |
| Wolff, Karin | born 1959 | Politician (CDU), 1999-2008 Minister of Education in Hesse |
| Ziesemer, Dominique Lars | born 1969 | TV presenter |
| Zöllner, Jürgen | born 1945 | Politician (SPD), 1991-2006 Minister of Education and Science in Rhineland-Palatinate |
| Zwanziger, Theo | born 1945 | Sports official, 2006-2012 DFB President |